Chronic RNA G-quadruplex accumulation in aging and Alzheimer's disease.

Lena Kallweit, Eric Daniel Hamlett, Hannah Saternos, Anah Gilmore, Ann-Charlotte Granholm, Scott Horowitz

Department of Chemistry & Biochemistry and the Knoebel Institute for Healthy Aging, University of Denver, Denver, United States. · pubmed

Paper

Abstract

As the world population ages, new molecular targets in aging and Alzheimer's disease (AD) are needed to combat the expected influx of new AD cases. Until now, the role of RNA structure in aging and neurodegeneration has largely remained unexplored. In this study, we examined human hippocampal

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Research summary

The paper claims that chronic accumulation of RNA G-quadruplexes contributes to aging and Alzheimer's disease. This research explores a novel molecular target related to the mechanisms of aging and neurodegeneration, which is relevant to longevity research.

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