Alda-1 mediates cell senescence and counteracts bone loss in weightlessness through regulating mitophagy.

Jinpeng Wang, Sen Li, Qiao Li, Qiuxin Yan, Yunhao Wang, Xiangyin Zeng, Fan Yang, Siyu Jiang, Manrui Zhang, Yaning Pi, Raza Tahir, Lijun Wei

School of Life Science and Technology, Faculty of Life Science and Medicine, Harbin Institute of Technology, No. 2 Yi Kuang Street, Harbin 150001, China. · pubmed

Paper

Abstract

Astronauts experience weightlessness-induced bone loss (WIBL) due to an imbalanced bone remodeling process involving bone mesenchymal stem cells (BMSCs), osteoblasts, and osteoclasts. Senescence is an important factor contributes to WIBL. In the current study, the effects of Alda-1 on senescence and WIBL were evaluated.

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Research summary

Alda-1 mediates cell senescence and counteracts bone loss in weightlessness through regulating mitophagy. The study addresses the role of cellular senescence in bone loss due to weightlessness, which is a relevant aspect of aging and its associated biological processes.

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