Time-restricted feeding reduces inflammatory markers and downregulates JAG1 and NICD protein levels in the liver of aged mice.

Ana Paula Azevêdo Macêdo, Ivo Vieira de Sousa Neto, Guilherme Correia Ferri Antonio, Rafael Calais Gaspar, Robson Damasceno de Lima, Larissa Moreira Dias, Renan Fudoli Lins Vieira, Vitor Rosetto Muñoz, Diego Trevisan Brunelli, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo Pauli

Laboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.Laboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira, São Paulo, Brazil. · pubmed

Paper

Abstract

The present study aimed to assess whether Time-Restricted Feeding (TRF) modulates inflammation and hepatic Notch1 signalling in C57BL/6J-aged mice.

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Research summary

Time-restricted feeding reduces inflammatory markers and downregulates JAG1 and NICD protein levels in the liver of aged mice. The study addresses the modulation of inflammation and signaling pathways associated with aging, which are relevant to understanding and potentially mitigating age-related decline.

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