Plasma homocysteine level and trajectories in association with longitudinal increase in plasma neurofilament light among urban adults.

May A Beydoun, Nicole Noren Hooten, Michael F Georgescu, Hind A Beydoun, Marie T Fanelli-Kuczmarski, Jordan Weiss, Michele K Evans, Alan B Zonderman

Laboratory of Epidemiology and Population Sciences, NIA Biomedical Research Center/NIH/IRP, Baltimore, MD, 21224, USA. [email protected] of Epidemiology and Population Sciences, NIA Biomedical Research Center/NIH/IRP, Baltimore, MD, 21224, USA. [email protected]. · pubmed

Paper

Abstract

We tested whether homocysteine (Hcy) was linked to longitudinal change in plasma neurofilament light chain (NfL) overall and differentially across sex and race in a sample of middle-aged urban adults. We used data from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study [n = 690, Age at visit 1 (v

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Research summary

The paper investigates the association between plasma homocysteine levels and changes in plasma neurofilament light chain among urban adults. This research is relevant as it explores potential biomarkers related to neurodegeneration, which can contribute to understanding aging processes and age-related diseases.

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