Andrias davidianus Derived Glycosaminoglycans Direct Diabetic Wound Repair by Reprogramming Reparative Macrophage Glucolipid Metabolism.

Peng Yang, Yifei Lu, Weiming Gou, Yiming Qin, Xingyue Zhang, Jingyuan Li, Qiong Zhang, Xiaorong Zhang, Dengfeng He, Yangping Wang, Dongdong Xue, Menglong Liu, Yu Chen, Junyi Zhou, Ximu Zhang, Junjiang Lv, Jianglin Tan, Gaoxing Luo, Qing Zhang

Institute of Burn Research, State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.Institute of Burn Research, State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China. · pubmed

Paper

Abstract

Harnessing cross-species regenerative cues to direct human regenerative potential is increasingly recognized as an excellent strategy in regenerative medicine, particularly for addressing the challenges of impaired wound healing in aging populations. The skin mucus of Andrias davidianus plays a critical role in self-protection and tissue repair, yet the fundamental regenerative factors and mechanisms involved remain elusive. Here, this work presents evidence that glycosaminoglycans (GAGs) derived from the skin secretion of Andrias davidianus (SAGs) serve as potent mediators of angiogenesis and inflammatory remodeling, facilitating efficient healing of diabetic wounds. Mechanistic studies reveal that SAGs promote macrophage polarization toward an anti-inflammatory and pro-regenerative phenotype (CD206

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Research summary

Glycosaminoglycans derived from Andrias davidianus enhance diabetic wound healing by reprogramming macrophage metabolism. This research addresses impaired wound healing, a significant issue in aging populations, suggesting potential mechanisms that could contribute to improved regenerative capacity in age-related conditions.

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