Targeting the NLRP3 in macrophages contributes to senescence cell clearance in radiation-induced skin injury.

Gaoyu Liu, Yan Chen, Shijie Dai, Gang Wu, Fulong Wang, Wanchao Chen, Lingling Wu, Peng Luo, Chunmeng Shi

Institute of Rocket Force Medicine, State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University (Army Medical University), Chongqing, 400038, China.Institute of Rocket Force Medicine, State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University (Army Medical University), Chongqing, 400038, China. · pubmed

Paper

Abstract

The persistent accumulation of senescence cells is one of the characteristics of radiation-induced skin injury (RISI), leading to fibrosis and impaired healing. However, the reasons why these senescence cells are resistant to clearance remain unclear.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Targeting NLRP3 in macrophages enhances the clearance of senescent cells in radiation-induced skin injury. This research addresses the accumulation of senescent cells, which is a hallmark of aging and contributes to age-related tissue damage, thus linking it to longevity and potential interventions in age-related diseases.

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