Diminazine protects against cardiac aging through the improvement of mitophagy and apoptosis in aging rats induced by D-galactose.

Ensiyeh Velayati, Abdolrahman Sarihi, Mohammad Zarei, Alireza Komaki, Fatemeh Ramezani-Aliakbari

Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. · pubmed

Paper

Abstract

Mitochondrial dysfunction is a main feature of the aged heart. However, there is still no effective treatment against cardiac aging. Diminazine (DIZE) is an anti-infective agent for animals. It is effective against cardiac disorders. The present study aimed to investigate the effects of DIZE on age-related cardiac dysfunction.

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Research summary

Diminazine improves mitophagy and apoptosis in aging rats, potentially addressing cardiac aging. The study targets mitochondrial dysfunction, a key aspect of aging, suggesting a possible intervention for age-related cardiac issues.

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