Cellular senescence as a key player in chronic heart failure pathogenesis: Unraveling mechanisms and therapeutic opportunities.
Abstract
Chronic heart failure (CHF) is the final stage of heart disease and is caused by various factors. Unfortunately, CHF has a poor prognosis and a high mortality rate. Recent studies have found that aging is a significant risk factor for the development of CHF and that cellular senescence plays a vital role in its development. This article reviews different types of cellular senescence, mitochondrial dysfunction in senescent cells, autophagy in senescent cells, and senescence-associated secretory phenotype (SASP), and epigenetic regulation, to provide new perspectives on the research and treatment of CHF.
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Research summary
Cellular senescence contributes to the pathogenesis of chronic heart failure through mechanisms such as mitochondrial dysfunction and the senescence-associated secretory phenotype. The paper is relevant as it explores the underlying mechanisms of aging-related cellular processes that may lead to chronic heart failure, thus addressing root causes of age-related diseases.
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