Ceria Nanoparticles Improve the Quality of Aging Oocytes in Mice by Enhancing ROS Scavenging Ability.

Yuchan Wang, Chengkun Zhong, Xin Ma, Xin Liu, Biao Zhang, Changguo Min, Kaiyan Zhang, Xinhai Wang, Shengkui Hou, Jing Zhao, Jun Wang, Yi Fang, Hongyu Liu, He Ding, Jing Guo, Yan Cheng, Wenfa Lu

Key Lab of the Animal Production, Product Quality, and Security, Ministry of Education, College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin 130118, China.Key Lab of the Animal Production, Product Quality, and Security, Ministry of Education, College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin 130118, China. · pubmed

Paper

Abstract

If fertilization does not occur in a timely manner after ovulation, then that can lead to aging and a decline in relation to oocyte quality, which have detrimental effects on subsequent embryo development and offspring. Reactive oxygen species (ROS) induced oxidative stress is the main factor in the deterioration of oocyte aging. Herein, ceria nanoparticles (NPs) have been developed as ROS scavengers to improve the quality of aging oocytes. We found that ceria NPs could effectively inhibit senescence-induced morphological changes and lower ROS accumulation in the oocytes. In addition, ceria NPs reduced the abnormal spindle distribution and improved mitochondrial function. Ceria NPs also reduced oxidative stress in aging oocytes by increasing ROS scavenging capacity rather than inhibiting ROS generation capacity. Furthermore, ceria NPs increased the rate of blastocyst formation in aging oocytes. We conclude that ceria NPs can enhance the quality and development potential of aging oocytes by reducing the level of oxidative stress.

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Research summary

Ceria nanoparticles can improve the quality of aging oocytes by enhancing their ROS scavenging ability. This research addresses a mechanism related to oxidative stress in aging oocytes, which is relevant to understanding and potentially mitigating aspects of reproductive aging.

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