Effect and mechanism of miRNA-144-5p-regulated autophagy in older adults with Sarcopenia.
Abstract
Advanced aging invariably triggers an overabundance of apoptosis, stemming from diminished autophagy or a disarray in cellular autophagic processes. This, in turn, leads to an accelerated breakdown of muscle proteins, which exacerbates the ongoing deterioration of skeletal muscle and intensifies the severity of senile sarcopenia. This study aimed to investigate the role and mechanism of miRNA-regulated autophagy in senile sarcopenia.
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Research summary
The paper investigates the role of miRNA-144-5p in regulating autophagy to address the underlying mechanisms of sarcopenia in older adults. This research is relevant as it explores a potential intervention targeting autophagy, which is a fundamental process associated with aging and longevity.
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