Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial.

Brice Gaudilliere, Lei Xue, Amy S Tsai, Xiaoxiao Gao, Tiffany N McAllister, Martha Tingle, Gladys Porras, Igor Feinstein, Dorien Feyaerts, Franck Verdonk, Maximilian Sabayev, Julien Hedou, Edward A Ganio, Eloïse Berson, Martin Becker, Camilo Espinosa, Yeasul Kim, Benoit Lehallier, Esther Rawner, Chunmiao Feng, Derek F Amanatullah, James I Huddleston, Stuart B Goodman, Nima Aghaeepour, Martin S Angst

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA.Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA. · pubmed

Paper

Abstract

Preclinical evidence suggests that young plasma has beneficial effects on multiple organ systems in aged mice. Whether young plasma exerts beneficial effects in an aging human population remains highly controversial. Despite lacking data, young donor plasma infusions have been promoted for age-related conditions. Given the preclinical evidence that young plasma exerts beneficial effects by attenuating inflammation, this study examined whether administering a young plasma protein fraction to an elderly population would exert anti-inflammatory and immune modulating effects in humans, using surgery as a tissue injury model.

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Research summary

The paper claims that administering a young plasma protein fraction to elderly patients can modify their immune and inflammatory response to surgical tissue injury. This study is relevant as it explores a potential intervention that may address underlying mechanisms of aging, specifically inflammation, rather than merely treating age-related symptoms.

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