Dynamic changes in the gut microbiota play a critical role in age-associated cognitive dysfunction via SCFAs and LPS synthesis metabolic pathways during brain aging.

Xiaoying Ma, Jiaying Liu, Lei Jiang, Zhaoyu Gao, Zhongli Shi, Nan Zhang, Zhen Wang, Shujin Li, Rui Zhang, Shunjiang Xu

Central Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang 050031, PR China; Hebei International Joint Research Center for Brain Science, Shijiazhuang 050031, PR China; Hebei Key Laboratory of Brain Science and Psychiatric-Psychologic Disease, Shijiazhuang 050031, PR China; College of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Hebei Province, Shijiazhuang 050017, PR China.Central Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang 050031, PR China; Hebei International Joint Research Center for Brain Science, Shijiazhuang 050031, PR China; Hebei Key Laboratory of Brain Science and Psychiatric-Psychologic Disease, Shijiazhuang 050031, PR China; College of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Hebei Province, Shijiazhuang 050017, PR China. · pubmed

Paper

Abstract

Gut microbiota plays an essential role in cognitive dysfunction during aging. The aim of this study was to investigate the dynamic alterations in the gut microbiota and screen for key gut bacterial taxa correlated with age-associated cognitive dysfunction during natural aging.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Dynamic changes in the gut microbiota are linked to age-associated cognitive dysfunction through metabolic pathways involving SCFAs and LPS synthesis. This paper is relevant as it explores the underlying mechanisms of cognitive decline in aging, which could contribute to understanding and potentially mitigating age-related cognitive dysfunction.

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