Age-Related Impairments in Immune Cell Efferocytosis and Autophagy Hinder Atherosclerosis Regression.

Dominique M Boucher, Sabrina Robichaud, Victoria Lorant, Jonathan S Leon, Issraa Suliman, Adil Rasheed, Leah I Susser, Christina Emerton, Michele Geoffrion, Erica De Jong, Dawn M E Bowdish, Masanori Aikawa, Elena Aikawa, Sasha A Singh, Katey J Rayner, Mireille Ouimet

Department of Biochemistry, Microbiology and Immunology, University of Ottawa, ON, Canada (D.M.B., S.R., V.L., I.S., A.R., L.I.S., K.J.R., M.O.). · pubmed

Paper

Abstract

Aging is a well-established risk factor for the development and progression of atherosclerosis, but the molecular mechanisms underlying this relationship remain poorly defined, and its role in atherosclerosis regression is unknown. To uncover age-related alterations that may impair atherosclerosis regression, we investigated the response of young and old macrophages to atherogenic lipoproteins in vitro and in vivo.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that age-related impairments in immune cell efferocytosis and autophagy hinder atherosclerosis regression. This research is relevant as it explores the molecular mechanisms linking aging to atherosclerosis, potentially addressing root causes of age-related diseases.

Author of this paper? Send a correction.