EZH2 inhibits senescence-associated inflammation and attenuates intervertebral disc degeneration by regulating the cGAS/STING pathway via H3K27me3.

Jianrui Zheng, Zetao Ma, Pei Liu, Jiewen Wei, Shaoxiong Min, Ying Shan, Jianlin Zhang, Ye Li, Lixiang Xue, Zhen Tan, Deli Wang

Department of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518000, PR China. Electronic address: [email protected] of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518000, PR China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Senescent nucleus pulposus mesenchymal stem cells (NPMSCs) are key instigators of local chronic inflammation and disruptions in nucleus pulposus tissue repair in intervertebral disc degeneration (IVDD). This study aimed to investigate the interplay between EZH2 and NPMSCs senescence-associated inflammation.

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Research summary

EZH2 inhibits senescence-associated inflammation in NPMSCs to attenuate intervertebral disc degeneration. The study addresses the role of cellular senescence and inflammation in a specific aging-related condition, which aligns with the exploration of mechanisms underlying age-related degeneration.

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