Delivering miR-23b-3p by small extracellular vesicles to promote cell senescence and aberrant lipid metabolism.

Ye Jin, Gaoge Sun, Binxian Chen, Siqin Feng, Muyun Tang, Hui Wang, Ying Zhang, Yuan Wang, Yang An, Yu Xiao, Zihan Liu, Peng Liu, Zhuang Tian, Hang Yin, Shuyang Zhang, Xiaodong Luan

Rare Disease Medical Center, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, 100730, China.Rare Disease Medical Center, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, 100730, China. · pubmed

Paper

Abstract

Aging is a natural process that affects the majority of organs within the organism. The liver, however, plays a pivotal role in maintaining the organism's homeostasis due to its robust regenerative and metabolic capabilities. Nevertheless, the liver also undergoes the effects of aging, which can result in a range of metabolic disorders. The function of extracellular vesicles and the signals they convey represent a significant area of interest within the field of ageing research. However, research on liver ageing from the perspective of EVs remains relatively limited.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that delivering miR-23b-3p via small extracellular vesicles can promote cell senescence and aberrant lipid metabolism in the liver. This research is relevant as it explores mechanisms related to aging and metabolic disorders, focusing on the role of extracellular vesicles in liver aging, which could contribute to understanding the root causes of age-related metabolic dysfunctions.

Author of this paper? Send a correction.