Downregulation of STAT1 improved learning and memory impairments in aging mice.
Abstract
Cognitive impairment is a typical hallmark of aging in mice and humans. Here, we reported that downregulation of STAT1 improved learning and memory impairments in aging mice by enhancing the expression of synaptic protein and inhibiting the expression of inflammatory factors. Proteomic analysis revealed 139 differentially expressed proteins (DEPs) in the hippocampus of downregulated-STAT1 aging mice, compared with aging control mice. Functional classification of DEPs indicated that these mainly involved in inflammation, autophagy, synapse, mitochondria and apoptosis. The ClueGo analysis uncovered that the Wiki pathway of these DEPs were involved in proteasome degradation, IL-6 signaling pathway, signaling of hepatocyte growth factor receptor and so on. Taken together, downregulation of STAT1 may delay aging with multiple mechanisms.
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Research summary
Downregulation of STAT1 improves learning and memory impairments in aging mice. This study addresses a potential mechanism underlying cognitive decline in aging, which is a significant aspect of the aging process and could contribute to understanding interventions that target the root causes of age-related cognitive impairments.
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