Oral Citrate Supplementation Mitigates Age-Associated Pathologic Intervertebral Disc Calcification in LG/J Mice.

Olivia K Ottone, Jorge J Mundo, Boahen N Kwakye, Amber Slaweski, John A Collins, Qinglin Wu, Margery A Connelly, Fatemeh Niaziorimi, Koen van de Wetering, Makarand V Risbud

Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. · pubmed

Paper

Abstract

Despite the high prevalence of age-dependent intervertebral disc calcification, there is a glaring lack of treatment options for this debilitating pathology. We investigated the efficacy of long-term oral K

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Research summary

Oral citrate supplementation can reduce age-associated intervertebral disc calcification in LG/J mice. This research addresses a specific age-related pathology, suggesting a potential intervention that could contribute to longevity by mitigating a degenerative process associated with aging.

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