Traditional medicine Bazi Bushen potentiates immunosurveillance of senescent liver cancer cells via cGAS-STING signaling activation in macrophages.

Fuxue Xing, Hongwei Lv, Wei Xiang, Liang Wang, Qianni Zong, Guishuai Lv, Chunying Liu, Qiyu Feng, Hongyang Wang, Wen Yang

Department of Cancer Research Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230027, China. · pubmed

Paper

Abstract

Senescent cancer cells often evade immune clearance to exert profound effects on cancer progression and therapy resistance. Improving immunosurveillance to eliminate senescent cancer cells is a crucial measure to enhance anti-cancer therapy. Bazi Bushen (BZBS) is a traditional medicine with the function of relieving fatigue and delaying ageing, but its role in tumor treatment remains poorly understood. Herein, we find that BZBS promotes immunosurveillance of both chemotherapy- and oncogene-induced senescent liver cancer cells, further leading to enhanced chemotherapy efficacy and dramatic tumor repression in mice. Mechanistically, BZBS induces mitochondrial DNA leakage by mitochondrial damage to further activate cGAS-STING signaling in macrophages. Subsequently, cGAS-STING signaling activation in macrophages recruits CD8

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Research summary

Bazi Bushen enhances immunosurveillance of senescent liver cancer cells through cGAS-STING signaling activation in macrophages. The paper is relevant as it explores a traditional medicine's potential to improve immune responses against senescent cells, which is a critical aspect of addressing aging and its associated diseases.

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