Comparison between the effect of mid-late-life high-intensity interval training and continuous moderate-intensity training in old mouse hearts.
Abstract
The impact of mid-late-life exercise on the aging heart remains unclear, particularly the effects of high-intensity interval training (HIIT) and continuous moderate-intensity training (CMIT). This study was the first to examine cardiac function, tissue characteristics, electrical remodeling, mitochondrial morphology and homeostasis in old mice subjected to CMIT or HIIT, compared to untrained controls. Our results showed that 8-week HIIT significantly improved the survival rate of old mice. HIIT presented advantages on cardiac function, deposition of collagen fibers, neovascularization, aging biomarkers and mitochondrial homeostasis. Only CMIT alleviated age-related cardiac hypertrophy. However, CMIT potentially exacerbated adverse cardiac electrical remodeling. Those findings suggested HIIT as a particularly appealing option for clinical application for aging populations.
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
High-intensity interval training (HIIT) improves cardiac function and survival rates in aging mice compared to continuous moderate-intensity training (CMIT). This study addresses the effects of exercise on aging-related cardiac function, which is crucial for understanding interventions that may mitigate age-related decline.
Author of this paper? Send a correction.