Microbiota protect against frailty, loss of skeletal muscle, and maintain inflammatory tone during aging in mice.

Meghan O Conn, Erica N DeJong, Daniel M Marko, Russta Fayyazi, Dana Kukje Zada, Kevin P Foley, Nicole G Barra, Dawn M E Bowdish, Jonathan D Schertzer

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada. · pubmed

Paper

Abstract

Chronic low-level inflammation or "inflammaging" is hypothesized to contribute to sarcopenia and frailty. Resident microbiota are thought to promote inflammaging, frailty, and loss of skeletal muscle mass. We tested immunity and frailty in male C57BL6/N germ-free (GF), specific-pathogen-free (SPF), and mice that were born germ-free and colonized (COL) with an SPF microbiota. Male and female GF mice had lower systemic cellular inflammation indicated by lower blood Ly6C

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Research summary

The paper claims that resident microbiota play a protective role against frailty and loss of skeletal muscle during aging. This research is relevant as it explores the relationship between microbiota and chronic inflammation, which are both implicated in the aging process and age-related decline.

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