Changes in adropin levels in brain and peripheral tissues with aging.

Changjun Yang, John Aaron Howell, Lei Liu, Rachel E Gunraj, Eduardo Candelario-Jalil

Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. · pubmed

Paper

Abstract

Adropin is a bioactive peptide found in the brain and various peripheral tissues. Evidence suggests that aging significantly decreases brain adropin levels, and interventions that elevate adropin may help alleviate age-related neurological disorders such as ischemic stroke and cognitive decline. However, the impact of aging on peripheral tissue adropin levels and its relationship with the neural recognition molecule NB-3/contactin-6 in the brain remains unclear. In this study, we quantified adropin using immunoblotting in brain and peripheral tissues (liver, lung, kidney, spleen, ileum, colon) from young (8-10 weeks) and aged (18-20 months) male mice. Results indicated a significant decrease in brain adropin levels in aged mice, while peripheral tissues showed no significant changes compared to young controls. Additionally, levels of NB-3/contactin-6, a potential adropin receptor and Notch1 ligand, were lower in aged brains. Co-immunoprecipitation demonstrated that adropin physically associates with brain NB-3. Notably, the age-related reduction in brain adropin correlates with increased oxidative stress markers (gp91

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Research summary

The paper claims that aging leads to a significant decrease in brain adropin levels, which may be linked to age-related neurological disorders. This research is relevant as it explores the biological mechanisms of aging and potential interventions that could address age-related decline in brain function.

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