Epigenetic age acceleration is related to cognitive decline in the elderly: Results of the Austrian Stroke Prevention Study.

Piyush Gampawar, Sai Pavan Kumar Veeranki, Katja-Elisabeth Petrovic, Reinhold Schmidt, Helena Schmidt

Research Unit-Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.Research Unit-Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria. · pubmed

Paper

Abstract

Epigenetic clocks, quantifying biological age through DNA methylation (DNAmAge), have emerged as potential indicators of brain aging. As the variety of DNAmAge algorithms grows, consensus on their efficacy in predicting age-related changes is lacking. This study aimed to explore the intricate relationship between diverse DNAmAge algorithms and structural and cognitive markers of brain aging.

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Research summary

The paper claims that epigenetic age acceleration, as measured by various DNAmAge algorithms, is associated with cognitive decline in the elderly. This study is relevant as it explores biological markers of aging that could potentially inform interventions aimed at understanding and mitigating age-related cognitive decline.

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