CircSPG21 ameliorates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells and mitigates intervertebral disc degeneration through the miR-217/SIRT1 axis and mitophagy.
Abstract
The microenvironment of intervertebral disc degeneration (IVDD) is characterized by oxidative stress, leading to the senescence of nucleus pulposus-derived mesenchymal stem cells (NPMSCs). The purpose of this study was to investigate the competitive endogenous RNA mechanism involved in the senescence of NPMSCs induced by tert-butyl hydroperoxide (TBHP).
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Research summary
CircSPG21 mitigates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells through the miR-217/SIRT1 axis and mitophagy. The study addresses oxidative stress and cellular senescence, which are key factors in the aging process and intervertebral disc degeneration, linking it to potential longevity implications.
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