Melatonin alleviates senile osteoporosis by regulating autophagy and enhancing fracture healing in aged mice.

Denghui Zhang, Tianer Zhu, Jingyao Bai, Chunchun Chen, Junru Wen, Yi Zhou, Xiaoxu Guan

The Affiliated Hospital of Stomatology, School of Stomatology, Zhejiang University of Medicine, and Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou, China. · pubmed

Paper

Abstract

In our previous research, we have found that melatonin (MEL) affects the osteoporotic process. By balancing bone remoulding, autophagy is involved in age-related bone loss. However, as a regulator of autophagy, whether MEL influences senile osteoporosis via regulating autophagy remains unclear.

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Research summary

Melatonin regulates autophagy to alleviate senile osteoporosis and enhance fracture healing in aged mice. The paper addresses a mechanism related to age-related bone loss, which is a significant aspect of aging and longevity research.

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