Age-related changes in DNA methylation in a sample of elderly Brazilians.

Hayley Welsh, Caio M P F Batalha, Weili Li, Nadja C Souza-Pinto, Yeda A O Duarte, Michel S Naslavsky, Esteban J Parra

Department of Anthropology, University of Toronto at Mississauga, Mississauga, Canada. [email protected]. · pubmed

Abstract

Age-related changes in DNA methylation (DNAm) play a critical role in regulating gene expression. However, most epigenome-wide association studies have predominantly focused on individuals of European descent. This study aims to characterize longitudinal changes in DNAm patterns in a cohort of elderly Brazilian participants.

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Research summary

This study characterizes longitudinal changes in DNA methylation patterns in elderly Brazilians. The research addresses age-related biological changes, which are fundamental to understanding the mechanisms of aging.

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