Rhythms and shifts of chemokines and cytokines interplay in a decade lifespan: The longitudinal community-based Bambuí health and aging study.

Joaquim Pedro Brito-de-Sousa, Maria Luiza Lima-Silva, Ismael Artur Costa-Rocha, Ana Carolina Campi-Azevedo, Juliana Vaz de Melo Mambrini, Ana Maria Caetano Faria, Maria Fernanda Lima-Costa, Sérgio Viana Peixoto, Andréa Teixeira-Carvalho, Karen Cecília Lima Torres, Olindo Assis Martins-Filho

Programa de Pós-graduação em Imunologia e Parasitologia Aplicadas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.Programa de Pós-graduação em Imunologia e Parasitologia Aplicadas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil. · pubmed

Paper

Abstract

Aging is associated with several physiological changes, including a remarkable remodeling of the immune system. Herein, the rhythms and shifts in serum immune mediators were characterized in a decade lifespan as a longitudinal community-based prospective investigation from Bambuí Health and Aging Study. The study population included paired samples from 713 subjects survivors from the original BHAS cohort and at 10-years Follow-up, categorized into 5-years age range intervals (60-64

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Research summary

The paper investigates the longitudinal changes in immune mediators over a decade in aging individuals. This study is relevant as it explores the immune system's remodeling, which is a fundamental aspect of aging and could provide insights into the biological mechanisms underlying longevity and age-related diseases.

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