Quercetin prevents the loss of chondrogenic capacity in expansion cultured human auricular chondrocytes by alleviating mitochondrial dysfunction.

Hua Tong, Xudong Guo, Lili Chen, Honglei Wang, Xuerui Hu, Aijuan He, Chenlong Li, Tianyu Zhang, Jiuhong Kang, Yaoyao Fu

Department of Facial Plastic and Reconstructive Surgery, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.Department of Facial Plastic and Reconstructive Surgery, Eye & ENT Hospital, Fudan University, Shanghai 200031, China. · pubmed

Paper

Abstract

To explore the characteristics of cellular senescence in human auricular chondrocytes during long-term in vitro culture and to evaluate the effects of anti-senescence treatments on enhancing their chondrogenic function.

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Research summary

Quercetin treatment preserves the chondrogenic capacity of human auricular chondrocytes during long-term culture by mitigating mitochondrial dysfunction. This research addresses cellular senescence, a fundamental aspect of aging, and explores potential interventions to enhance cellular function, which is relevant to longevity studies.

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