Crassifolin A prolongs lifespan and healthspan in Caenorhabditis elegans via activating autophagy.

Wenyu Dai, Lifeng Deng, Chenyang He, Xiaoxia Fu, Jing Liu, Guo-Cai Wang, Jing Yang, Yu-Bo Zhang, Fei Xiao, Qin-Li Wan

Department of Pathogen Biology, School of Medicine, Jinan University, Guangzhou, 510632, Guangdong, China; The College of Life Science and Technology, Jinan University, Guangzhou, 510632, Guangdong, China.Department of Pathogen Biology, School of Medicine, Jinan University, Guangzhou, 510632, Guangdong, China; The College of Life Science and Technology, Jinan University, Guangzhou, 510632, Guangdong, China. · pubmed

Paper

Abstract

The root of Croton crassifolius Geiseler (C. crassifolius), commonly known as "Jiguxiang" in traditional Chinese medicine, is globally recognized for its ethnomedical applications in treating a spectrum of diseases. Crassifolin A (CA), a diterpenoid compound extracted from the roots of C. crassifolius, exhibits anti-herpes simplex virus (HSV), anti-viral and anti-angiogenic properties.

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Research summary

Crassifolin A prolongs lifespan and healthspan in Caenorhabditis elegans via activating autophagy. The study investigates a compound that appears to directly influence mechanisms associated with aging and lifespan extension, aligning with the goals of longevity research.

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