DNA methylation-based age prediction and sex-specific epigenetic aging in a lizard with female-biased longevity.
Abstract
Sex differences in life span are widespread across animal taxa, but their causes remain unresolved. Alterations to the epigenome are hypothesized to contribute to vertebrate aging, and DNA methylation-based aging clocks allow for quantitative estimation of biological aging trajectories. Here, we investigate the influence of age, sex, and their interaction on genome-wide DNA methylation patterns in the brown anole (
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Research summary
The paper investigates the relationship between DNA methylation patterns and biological aging in a lizard, highlighting sex-specific differences in longevity. This research contributes to understanding the epigenetic factors influencing aging and lifespan, which is central to longevity studies.
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