Defective Cystic Fibrosis Transmembrane Conductance Regulator Accelerates Skeletal Muscle Aging by Impairing Autophagy/Myogenesis.

Ziyi Chen, Jiankun Xu, Peijie Hu, Wanting Du, Junjiang Chen, Xiaotian Zhang, Wei Zhou, Jiayang Gao, Yuantao Zhang, Bingyang Dai, Guangshuai Nie, Jun Hu, Liangbin Zhou, Shunxiang Xu, Hisao Chang Chan, Wing-Hoi Cheung, Ye Chun Ruan, Ling Qin

Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, China.Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, China. · pubmed

Paper

Abstract

Regenerative capacity of skeletal muscles decreases with age. Deficiency in cystic fibrosis transmembrane conductance regulator (CFTR) is associated with skeletal muscle weakness as well as epithelial cell senescence. However, whether and how CFTR plays a role in skeletal muscle regeneration and aging were unclear.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that defective CFTR accelerates skeletal muscle aging by impairing autophagy and myogenesis. This research is relevant as it explores the mechanisms underlying skeletal muscle aging, which is a critical aspect of the aging process and could inform strategies for longevity and age-related muscle degeneration.

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