Endothelial dysfunction in middle-aged and older men with low testosterone is associated with elevated circulating endothelin-1.

Matthew C Babcock, Lyndsey DuBose, Kerry L Hildreth, Brian L Stauffer, Wendy M Kohrt, Megan M Wenner, Kerrie L Moreau

Division of Geriatric Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.Division of Geriatric Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO. · pubmed

Paper

Abstract

Low testosterone in middle-aged/older men contributes to accelerated vascular aging, including endothelial dysfunction. However, the mechanisms by which low testosterone affects endothelial dysfunction are not well understood. We sought to determine whether higher endothelin-1 (ET-1) levels are associated with reduced brachial artery flow-mediated dilation (FMD) in middle-aged/older men with low testosterone.

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Research summary

The paper claims that higher endothelin-1 levels are associated with reduced brachial artery flow-mediated dilation in middle-aged/older men with low testosterone. This research addresses a potential mechanism linking low testosterone to vascular aging, which is relevant to understanding age-related diseases and the biological processes of aging.

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