Assessment of relationships between epigenetic age acceleration and multiple sclerosis: a bidirectional mendelian randomization study.

Hongwei Liu, Hanqing Zhang, Zhaoxu Yin, Miaomiao Hou

Department of Neurology, Taiyuan Central Hospital, Taiyuan, Shanxi Province, China.Department of Neurology, Taiyuan Central Hospital, Taiyuan, Shanxi Province, China. · pubmed

Paper

Abstract

The DNA methylation-based epigenetic clocks are increasingly recognized for their precision in predicting aging and its health implications. Although prior research has identified connections between accelerated epigenetic aging and multiple sclerosis, the chronological and causative aspects of these relationships are yet to be elucidated. Our research seeks to clarify these potential causal links through a bidirectional Mendelian randomization study.

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Research summary

The paper investigates the causal relationships between epigenetic age acceleration and multiple sclerosis. This research is relevant as it explores the underlying mechanisms of aging through epigenetic factors, which could contribute to understanding age-related diseases.

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