Accelerated epigenetic aging worsens survival and mediates environmental stressors in fibrotic interstitial lung disease.

Gillian C Goobie, Daniel-Costin Marinescu, Ayodeji Adegunsoye, Jean Bourbeau, Christopher Carlsten, Rachel L Clifford, Dany Doiron, Qingling Duan, Kevin F Gibson, Amanda Grant-Orser, Ana I Hernandez Cordero, Kerri A Johannson, Daniel J Kass, Sharon E Kim, Janice M Leung, Xiaoyun Li, Wan Tan, Chen Xi Yang, S Mehdi Nouraie, Christopher J Ryerson, Tillie L Hackett, Yingze Zhang

Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, B.C., Canada [email protected]. · pubmed

Paper

Abstract

The role of epigenetic aging in the environmental pathogenesis and prognosis of fibrotic interstitial lung disease (fILD) is unclear. We evaluated whether ambient particulate matter ≤2.5 μm (PM

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that accelerated epigenetic aging mediates the effects of environmental stressors on survival in fibrotic interstitial lung disease. This research is relevant as it explores the role of epigenetic aging in disease progression, potentially addressing underlying mechanisms of aging and their impact on health outcomes.

Author of this paper? Send a correction.