Beneficial effects of the herbal medicine zuo gui wan in a mice model of Alzheimer's disease via Drp1-Mediated inhibition of mitochondrial fission and activation of AMPK/PGC-1α-regulated mitochondrial bioenergetics.

Xirui Yan, Yifang Yang, Weiling Huang, Shuping Fu, Bo Cui, Min Chu, Yang Dong, Yinting Peng, Haiyan Song, Jianrong Shi, Qing Liu

School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Department of Otolaryngology, Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Department of Otolaryngology, Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. · pubmed

Paper

Abstract

Zuo Gui Wan (ZGW) is a well-known traditional Chinese medicine decoction used for approximately 400 years to treat age-related degenerative conditions, including cognitive impairment in older adults, osteoporosis, and general aging. However, the mechanism of action for ZGW remains unclear.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that Zuo Gui Wan exerts beneficial effects in a mouse model of Alzheimer's disease through the inhibition of mitochondrial fission and activation of mitochondrial bioenergetics. The study is relevant as it explores a traditional medicine's potential mechanisms that may address underlying biological processes associated with aging and age-related diseases.

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