Establishment and application of a zebrafish model of Werner syndrome identifies sapanisertib as a potential antiaging drug.

Jianlong Ma, Yang Chen, Jingmei Song, Qingfeng Ruan, Lianghui Li, Lingfei Luo

State Key Laboratory of Genetic Engineering, School of Life Sciences, Liver Cancer Institute of Zhongshan Hospital, Fudan University, Shanghai 200438, China.State Key Laboratory of Genetic Engineering, School of Life Sciences, Liver Cancer Institute of Zhongshan Hospital, Fudan University, Shanghai 200438, China. · pubmed

Paper

Abstract

Aging is a complex process that affects multiple organs, and the discovery of a pharmacological approach to ameliorate aging is considered the Holy Grail of medicine. Here, we performed an N-ethyl-N-nitrosourea forward genetic screening in zebrafish and identified an accelerated aging mutant named

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Research summary

The paper identifies sapanisertib as a potential antiaging drug through a zebrafish model of Werner syndrome. This research is relevant as it explores a pharmacological approach to address the underlying mechanisms of aging rather than merely treating age-related symptoms.

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