A Natural Autophagy Activator Castanea crenata Flower Alleviates Skeletal Muscle Ageing.

So-Hyun Park, Pyeong Geun Choi, Hee-Soo Kim, Eunyoung Lee, Da-Hye Lee, Min Jung Kim, Daedong Kim, Hyo-Deok Seo, Jeong-Hoon Hahm, Tae-Il Jeon, Yang-Hoon Huh, Jiyun Ahn, Tae-Youl Ha, Chang Hwa Jung

Aging and Metabolism Research Group, Korea Food Research Institute, Wanju-gun, Jeollabuk-do, Republic of Korea.Aging and Metabolism Research Group, Korea Food Research Institute, Wanju-gun, Jeollabuk-do, Republic of Korea. · pubmed

Paper

Abstract

Sarcopenia, characterized by a gradual decline in skeletal muscle mass and function with age, significantly impacts both quality of life and mortality. Autophagy plays a crucial role in maintaining muscle health. There is growing interest in leveraging autophagy to mitigate muscle ageing effects. The impact of natural autophagy activators on skeletal muscle ageing remains elusive. This study aims to identify natural autophagy activators and assess their effects on skeletal muscle ageing.

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Research summary

The paper claims that a natural autophagy activator, Castanea crenata flower, can alleviate skeletal muscle ageing. This research is relevant as it explores potential interventions targeting autophagy, which is a fundamental process in addressing the root causes of aging and age-related decline in muscle health.

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