Sirtuin 1 Suppresses Hydrogen Peroxide-Induced Senescence and Promotes Viability and Migration in Lens Epithelial Cells by Inhibiting Forkhead Box Protein O1/Toll-Like Receptor 4 Pathway.

Hongda Jiang, Yuting Liu, Yinggui Yu, Yu Yan

Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. · pubmed

Paper

Abstract

Age-related cataracts (ARCs) are associated with increased oxidative stress and cellular senescence. Our objective is to investigate the function of Sirtuin 1 (SIRT1) within ARCs. In ARCs tissues and H

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Research summary

Sirtuin 1 (SIRT1) inhibits the Forkhead Box Protein O1/Toll-Like Receptor 4 pathway to suppress oxidative stress-induced senescence in lens epithelial cells. This research addresses the cellular mechanisms involved in age-related cataracts, which are linked to aging processes and oxidative stress, thus contributing to the understanding of aging-related cellular dysfunction.

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