Increased matrix metalloproteinase-1 expression by coexposure to UVA and cigarette sidestream smoke and contribution of histone acetylation.

Ryoma Ito, Yukako Komaki, Yuko Ibuki

Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Yada 52- 1, Suruga-ku, Shizuoka, 422-8526, Japan.Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Yada 52- 1, Suruga-ku, Shizuoka, 422-8526, Japan. · pubmed

Paper

Abstract

Skin is exposed to various environmental factors throughout life, and some of these factors are known to contribute to skin aging. Long-term solar UV exposure is a well-known cause of skin aging, as is cigarette smoke, which contains a number of chemicals. In this study, combined effect of UVA and cigarette sidestream smoke (CSS) on matrix metalloproteinase-1 (MMP-1) induction was investigated. MMP-1 is the main protease that initiates collagen type I fiber fragmentation in human skin and is associated with aging.

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Research summary

The paper claims that coexposure to UVA and cigarette sidestream smoke increases MMP-1 expression, contributing to skin aging. This research is relevant as it investigates environmental factors that contribute to the biological mechanisms of skin aging, which is a significant aspect of longevity research.

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