The association of visceral and subcutaneous fat areas with phenotypic age in non-elderly adults, mediated by HOMA-IR and HDL-C.

Yuanhong Liu, Min Xu, Liqing Wang, Linyun Meng, Mengran Li, Shumin Mu

The First Clinical College of Shandong University of Traditional Chinese Medicine, Jinan City, 250014, Shandong Province, China.The First Clinical College of Shandong University of Traditional Chinese Medicine, Jinan City, 250014, Shandong Province, China. · pubmed

Paper

Abstract

Ageing results in diminished adaptability, as well as declines in physiological and psychological functions and resilience. The epigenetic clock 'Phenotypic Age' (PhenoAge) represents 'preclinical ageing'. Phenotypic Age Acceleration (PhenoAgeAccel) is defined as the residual from a linear regression model predicting PhenoAge on the basis of chronological age. Abdominal subcutaneous adipose tissue, visceral adipose tissue, the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), and high-density lipoprotein cholesterol (HDL-C) have all been shown to correlate with ageing; however, the connections between these factors and PhenoAge are still insufficiently investigated.

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Research summary

The paper investigates the association between visceral and subcutaneous fat areas and phenotypic age, mediated by insulin resistance and HDL-C levels. This research is relevant as it explores factors that may contribute to the biological processes of aging, potentially offering insights into the root causes of age-related changes.

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