Salivary gland stem/progenitor cells: advancing from basic science to clinical applications.

Jimpi Langthasa, Li Guan, Shyam Lal Jinagal, Quynh-Thu Le

Department of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Dr Clinic D, Stanford, CA, MC 584794305, USA.Department of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Dr Clinic D, Stanford, CA, MC 584794305, USA. · pubmed

Paper

Abstract

Salivary gland stem/progenitor cells (SSPCs) hold significant potential for regenerative medicine, especially for patients suffering from salivary gland dysfunction due to various causes such as radiation therapy, Sjögren's syndrome, and aging. This review provides a comprehensive overview of SSPCs, including their characteristics, isolation, culture techniques, differentiation pathways, and their role in tissue regeneration. Additionally, we highlight recent advances in cell- and tissue-based therapies, such as SSPC transplantation and bioengineered organ replacements. The challenges in translating SSPC research into effective clinical therapies are also discussed, alongside proposed solutions and future research directions.

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Research summary

Salivary gland stem/progenitor cells have potential for regenerative therapies in salivary gland dysfunction. The paper discusses the role of these cells in tissue regeneration, which is relevant to addressing age-related dysfunctions.

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