Mineral Stress Drives Loss of Heterochromatin: An Early Harbinger of Vascular Inflammaging and Calcification.

Chin Yee Ho, Meng-Ying Wu, Jirapath Thammaphet, Sadia Ahmad, James Ho C S, Lilia Draganova, Grace Anderson, Umesh S Jonnalagadda, Robert Hayward, Rukshana Shroff, Wilson Tan Lek Wen, Anja Verhulst, Roger Foo, Catherine M Shanahan

British Heart Foundation Centre for Research Excellence, School of Cardiovascular and Metabolic Medicine and Sciences, James Black Centre, King's College London, United Kingdom (C.Y.H., M.-Y.W., J.T., S.A., L.D., G.A., R.H., C.M.S.).British Heart Foundation Centre for Research Excellence, School of Cardiovascular and Metabolic Medicine and Sciences, James Black Centre, King's College London, United Kingdom (C.Y.H., M.-Y.W., J.T., S.A., L.D., G.A., R.H., C.M.S.). · pubmed

Paper

Abstract

Vascular calcification is a detrimental aging pathology markedly accelerated in patients with chronic kidney disease. Prelamin A is a biomarker of vascular smooth muscle cell aging that accelerates calcification however the mechanisms remain undefined.

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Research summary

Mineral stress leads to the loss of heterochromatin, which may contribute to vascular inflammaging and calcification. The paper is relevant as it explores mechanisms underlying vascular aging, which is a significant aspect of age-related diseases.

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