PLK3 weakens antioxidant defense and inhibits proliferation of porcine Leydig cells under oxidative stress.

Chujie Chen, Jinyan He, Weixian Huang, Dong Xu, Zhaohui Li, Anqi Yang

Department of Laboratory Animal Science, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan, China.Department of Laboratory Animal Science, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan, China. · pubmed

Paper

Abstract

Aging is characterized by cellular degeneration and impaired physiological functions, leading to a decline in male sexual desire and reproductive capacity. Oxidative stress (OS) lead to testicular aging by impairing the male reproductive system, but the potential mechanisms remain unclear. In the present study, the functional status of testicular tissues from young and aged boars was compared, and the transcriptional responses of Leydig cells (LCs) to hydrogen peroxide (H

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Research summary

The paper claims that PLK3 weakens antioxidant defense and inhibits proliferation of porcine Leydig cells under oxidative stress. This research is relevant as it explores the mechanisms of oxidative stress in relation to testicular aging, which could contribute to understanding the biological processes underlying aging and male reproductive decline.

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