Circulating lipocalin-2 across the adult lifespan.

Carlie Bauer, Cassandra Smith, Sara Vogrin, Andrew S Palmer, Mary Woessner, Shanie Landen, Macsue Jacques, Elizabeth Byrnes, Nir Eynon, Marc Sim, Joshua R Lewis, Itamar Levinger

Institute for Health and Sport, Victoria University, Melbourne, VIC 3011, Australia.Institute for Health and Sport, Victoria University, Melbourne, VIC 3011, Australia. · pubmed

Paper

Abstract

Lipocalin-2 (LCN2), a hormone produced by adipocytes, osteoblasts, and renal tubular cells, is implicated in age-related diseases, including cardio-metabolic disease. To understand the role LCN2 may play in pathological states, we first need to elucidate the relationship between circulating LCN2 with indices of cardio-metabolic health during "normal" aging. This study examined the relationship between serum levels of LCN2, age, and cardio-metabolic measures across the adult lifespan in males and females. We conducted a pooled cohort analysis including 124 community-dwelling males (

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Research summary

The paper investigates the relationship between circulating lipocalin-2 levels and cardio-metabolic health across the adult lifespan. This research is relevant as it explores a biomarker potentially linked to age-related diseases, contributing to the understanding of mechanisms involved in aging and longevity.

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