5-HT

Nathan R Kerr, Anna R Dashtmian, Fereshteh B Darvishi, Charles D Brennan, Sindhuja N Ayyagari, Peter J Moore, Jose A Viteri, Meifang Wang, Mark M Rich, Brian C Clark, W David Arnold

Department of Physical Medicine and Rehabilitation, University of Missouri, Columbia, MO, USA.Department of Physical Medicine and Rehabilitation, University of Missouri, Columbia, MO, USA. · pubmed

Paper

Abstract

Sarcopenia, the pathological age-related loss of muscle mass and strength, contributes to physical decline, frailty, and diminished healthspan. The impact of sarcopenia is expected to rise as the aging population grows, and treatments remain limited. Therefore, novel approaches for enhancing physical function and strength in older adults are desperately needed. Recent evidence suggests that deficits in motor neuron excitability contribute significantly to age-related weakness. Accordingly, we hypothesized that enhancing motor neuron excitability could be a novel strategy for mitigating age-related declines in physical function and strength. To test this hypothesis, we targeted the 5-HT

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Research summary

Enhancing motor neuron excitability could mitigate age-related declines in physical function and strength. The paper addresses a potential novel approach to combat sarcopenia, which is a significant age-related condition affecting healthspan and physical function in older adults.

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