Generation and Characterization of a New Aging Skin Human Dermal Extracellular Matrix Scaffold.
Abstract
In vitro skin aging models represent a valuable tool for the study of age-related pathologies and potential treatments. However, the currently available models do not adequately represent the complex microenvironment of the dermis since they generally focus on cutaneous cellular senescence, rather than the full range of factors that contribute to the aging process, such as structural and compositional alteration of the dermal extracellular matrix. The following protocol describes the extraction and characterization of human adult extracellular matrix scaffolds for use in in vitro aging models.
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Research summary
The paper presents a protocol for extracting and characterizing human dermal extracellular matrix scaffolds for in vitro aging models. This research is relevant as it addresses the structural and compositional changes in the dermal extracellular matrix, which are fundamental aspects of the aging process.
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