Focus on the Forgotten Organelle: Regulation of Lysosomes in Skeletal Muscle.
Abstract
Research on the role of the lysosome as the terminal organelle in autophagy and in communicating with other organelles in skeletal muscle is in its infancy. We hypothesize that the lysosome can adapt positively to exercise to improve the clearance of cargo, like dysfunctional mitochondria, within muscle, representing an important therapy for protein homeostasis in aging and muscle disuse.
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Research summary
The paper hypothesizes that lysosomes can adapt positively to exercise to enhance the clearance of dysfunctional mitochondria in skeletal muscle. This research is relevant as it addresses the role of lysosomes in maintaining protein homeostasis, which is crucial for combating age-related muscle decline and improving overall cellular health in the context of aging.
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