Novel insights into mechanisms and therapeutics for presbycusis.
Abstract
Presbycusis, also referred to as age-related hearing loss, poses a substantial burden on both individuals and society. The hallmark of presbycusis is a progressive decrease in auditory sensitivity. Irreversible hearing loss occurs due to the limited regenerative capacity of spiral neurons and peripheral cochlear hair cells (HCs). Although hearing aids and cochlear implantations (CIs) are established approaches for alleviating symptoms of presbycusis, there are currently no preventive or curative measures available. This article provides a comprehensive discussion on the research progress pertaining to the classification, molecular mechanism, genetic susceptibility, as well as the applications and prospects of diverse therapeutic interventions of presbycusis. Building upon these discussions, promising interventions like gene therapy and stem cell (SC) therapy are proposed for their potential value in restoring cochlear function; thus aiming to pave new avenues for prevention and cure of presbycusis.
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Research summary
The paper addresses presbycusis, which is an age-related condition, and discusses potential therapeutic interventions that could restore cochlear function. While it does not directly tackle the root causes of aging, it explores innovative approaches like gene therapy and stem cell therapy that could have implications for age-related hearing loss. However, the focus remains primarily on treatment rather than prevention or addressing the underlying mechanisms of aging, limiting its overall impact in the broader context of longevity research.
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