Associations of phenols, parabens, and phthalates with biological aging: stratified analyses by chronological age and lifestyle in NHANES 2005-2010.
Abstract
Humans are widely exposed to phenols, parabens, and phthalates with health risks, while the effects of these chemicals on biological aging remain unclear. Among 3,441 adults in the National Health and Nutrition Examination Survey 2005-2010, phenol, paraben, and phthalate concentrations were measured and phenotypic age acceleration (PhenoAgeAccel) was calculated. Linear regression and weighted quantile sum (WQS) regression were used to evaluate the associations of single and mixed chemicals with PhenoAgeAccel. Stratified analyses by chronological age and lifestyle were also performed. Individual phthalates were positively associated with PhenoAgeAccel. The WQS model found the positive relationship between mixed chemicals with PhenoAgeAccel (
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Research summary
The paper investigates the associations between certain chemicals and biological aging, specifically through the lens of phenotypic age acceleration. While it touches on biological aging, the focus on chemical exposure and its correlation with aging metrics does not directly address the root causes of aging or propose mechanisms for lifespan extension. The findings may contribute to understanding environmental factors in aging but do not present significant advancements in the field of longevity research. Thus, it is a solid piece of research but with limited impact.
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