Does Lifelong Exercise Counteract Low-Grade Inflammation Associated with Aging? A Systematic Review and Meta-Analysis.

Iñigo M Pérez-Castillo, Ricardo Rueda, Hakim Bouzamondo, Diego Aparicio-Pascual, Alberto Valiño-Marques, Jose López-Chicharro, Felipe Segura-Ortiz

Research and Development, Abbott Nutrition, 68 Camino de Purchil, 18004, Granada, Spain. [email protected]. · pubmed

Paper

Abstract

Aging is associated with sustained low-grade inflammation, which has been linked to age-related diseases and mortality. Long-term exercise programs have been shown to be effective to for attenuating this process; however, subsequent detraining might negate some of these benefits. Master athletes, as a model of lifelong consistent exercise practice, have been suggested to present similar inflammatory profiles to untrained young adults. Nonetheless, it is unclear whether maintaining training habits throughout life can completely counteract low-grade inflammation associated with aging.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper addresses the relationship between lifelong exercise and low-grade inflammation associated with aging, which is a relevant topic in longevity research. It explores the potential for exercise to mitigate a biological process linked to age-related diseases, thus contributing to our understanding of aging mechanisms. However, while the findings may be solid, they appear to be incremental rather than groundbreaking, limiting their overall impact on the field.

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