Associations of late mid‐life lifestyle with brain and cognitive changes in individuals on the AD vs. non‐AD continuum.

Julie Elisabeth Oomens, Karly Alex Cody, Lianlian Du, Erin M. Jonaitis, Rachel L Studer, Caitlin Artz, Madilynn Wintlend, Sebastian Köhler, Pieter Jelle Visser, Stephanie J. B. Vos, Rebecca E. Langhough, Willemijn J. Jansen, Sterling C. Johnson

Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, NetherlandsAlzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands · pubmed

Paper

Abstract

To aid development of prevention strategies, we investigated whether a composite measure of late‐midlife lifestyle health was associated with (1) change in brain tau burden, vascular burden and neurodegeneration and (2) cognitive trajectories when accounting for these brain changes.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the associations between late mid-life lifestyle factors and brain changes, which is relevant to understanding cognitive decline and neurodegeneration in the context of aging. However, it primarily focuses on correlational findings rather than addressing root causes of aging or proposing interventions that could significantly extend lifespan or healthspan. Thus, while it contributes solid research to the field, its impact is limited.

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